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Archive for the ‘Nanotech’ Category

RJR gifts help Piedmont Triad Research Park expand

Thursday, April 8th, 2010

Piedmont Triad Research Park illustrationWINSTON-SALEM, NC – R.J. Reynolds Tobacco Co. is giving the Piedmont Triad Research Park in Winston-Salem 38 acres of property and $2 million in cash to aid its expansion efforts.

RJR says the gifts are worth a total of $19 million. The company gave the PTRP 16 acres five years ago.

Susan Ivey, chair and CEO of RJR said, ““The property transfer, as well as the $2 million donation, will allow PTRP to continue its master-plan expansion and realize its vision of creating a vibrant life-sciences research and product development complex downtown.”

PTRP owns 172 acres now and plans to expand to 230 acres eventually.

PTRP’s best known tenant is the Wake Forest Institute for Regenerative Medicine, which is headed by regenerative medicine pioneer Dr. Anthony Atala.

Others include Targacept, and RJR spinout working on treatments for central nervous system disorders; Time Warner Telecom; Sunrise Technologies,

NanoMech names Blakely CEO

Thursday, March 18th, 2010

Keith Blakely

Keith Blakely

SPRINGDALE, ARK – NanoMech, a designer and manufacturer of nanoparticle additives and coatings for specific applications, has named Keith Blakley CEO.

Blakely has a history of successfully transforming startup companies into major technology enterprises. He spearheaded development of one of the leading advanced ceramic companies in the United States, Advanced Refractory Technologies, building it from a one-person startup to a multinational operation with multiple manufacturing facilities and over 325 employees.

Following this, he orchestrated the creation, development and growth of what at the time was one of the world’s leading nanotechnology companies, NanoDynamics. Under Blakely’s leadership the company developed over 120 patents and patent applications and brought three products to commercial viability in five years.

Blakely has delivered strategic executive consulting services to a number of other technology-driven organizations and has led successful turnarounds at several companies, resulting in their acquisition by major US corporations.

Blakely has served as the Director of the Center for Competitiveness for the Niagara Region of New York, and Chairman of the Board for the Western New York Technology Development Center. He was named the New York State Export Entrepreneur of the Year.

NanoMech’s scientists and engineers design a wide variety of nanocomposite materials and coatings that have properties such as extreme wear resistance, self-lubrication, antimicrobial action, biocompatibility and other attributes that benefit multiple industries. NanoMech’s suite of nanomaterials and manufacturing technologies holds numerous patents and patents pending.

www.nanmech.biz

Virginia’s Parabon NanoLabs successfully targets brain tumor cells

Thursday, February 18th, 2010

DNA

By Allan Maurer

RESTON, VA – Parabon NanoLabs has successfully targeted deadly brain cancer tumor cells in mice using its designer molecules, which it can build atom by atom. Eventually, the technology could lead to more effective treatments that may do away with side effects for the type of brain cancer that killed Sen. Edward Kennedy, as well as other types of tumors.

“The trouble with most anti-cancer chemo-therapies is that they target any rapidly dividing cell line,” says Steve Armentrout, CEO and founder of Parabon Computation, the Reston-based firm that spun-out Parabon NanoLabs in 2008.  Cells lining the stomach and hair cells are also rapidly dividing types. That’s why chemotherapy causes nausea and you lose your hair,” he explains.

Parabon NanoLabs is one of 60 highly innovative companies presenting at the upcoming Southeast Venture Conference in Tysons Corner, VA, Feb. 24-25 (See: www.seventure.org for more information). The company received grants under $500,000 and seeks to raise $1 million.

Wins NSF Grant

Parabon NanoLabs won a National Science Foundation Grant to demonstrate the viability of a new class of anticancer molecules that are engineered to automatically self-assemble from interlocking strands of synthetic DNA.

Parabon’s compounds are deliberately engineered to solve specific therapeutic goals using an approach that effectively replaces the current paradigm of “drug discovery” with that of “drug design.”

By affixing molecular subcomponents (e.g., antibodies, pharmaceuticals and enzymes) to strands of DNA that are pre-sequenced to attach to one another to form composite constructs, Parabon NanoLabs researchers produce therapeutics that are able to precisely target and destroy individual cancer cells, without damaging surrounding healthy tissue.

Parabon NanoLabs has advanced both the fabrication technology required to produce such therapeutics and the computational tools to design them.

Armentrout tells us the next step in the company’s brain cancer compound is to test payloads and determine their effectiveness. It is seeking a Phase II NSF grant to pursue that research.

Since it is a platform technology the company can branch out into other indications downstream.

Uses grid computing

Parabon Computation, NanoLabs’ parent company, uses its Frontier Grid platform to harness the idle cycles of thousands of computers to tackle difficult computation problems—nanotech among them, says Armentrout.

Grid systems use otherwise idle computer processing cycles to crunch small parts of big problems on many machines.

Parabon NanoLabs has developed a CAD (computer-aided design) application, called inSēquio, which facilitates the design and sequencing of therapeutic nanostructures by harnessing the computational power of the grid.

The company has also won a Department of Homeland Security (DNS) Small Business Innovation Research Grant to demonstrate the effectiveness of its SNP chip (snip chip), a briefcase-size biometrics device that will process a DNA sample and determine identity or kinship with an accuracy of 99.99 percent, in under 45 minutes, at a cost of less than $50.

Many applications possbile

The company says the device could have enormous commercial value across the homeland security, law enforcement, and defense industries.

The DNS says rapid DNA-based screening will reduce the fraud in asylum, refugee and overseas adoptions cases allowing DHS to focus on processing legitimate applications.

“Beyond DHS’ needs for kinship analysis, a rapid, low-cost DNA-based biometric will have broad applications in mass-casualty situations, reunification of family members following mass evacuations, identification of missing persons, rapid processing of crime-scene and suspect DNA and various scientific and educational uses.” Christopher A. Miles, DNS biometrics program manager, says.

Parabon NanoLabs says the technology and resultant nanostructures it can make have potentially limitless applications, ranging from detergent additives to next-generation electronics.

The ability to precisely manipulate matter at the nanoscale (it takes 24.5 million nanometers to make an inch) is expected to usher in the Nanotechnology Revolution, which the National Science Foundation estimates as having a market potential of $1 trillion by 2015.

Parabon NanoLabs is one of two companies with innovative nanotechnology products presenting at this years Southeast Venture Conference. BlueNano, which makes nanotech materials with a wide range of applications, is also presenting.

For TechJournal South’s previous story on Parabon Computation, see: Parabon Computation puts idle processing power to work

Online:

www.parabon.com

www.parabon-nanolabs.com

Blue Nano materials make better fuel cells, batteries and solar products

Tuesday, February 9th, 2010

By Allan Maurer

soloar cell photo

Solar cells are only one product Blue Nano materials improve

CHARLOTTE, NC –Blue Nano does not tell anyone how it makes its high nanotechnology materials that help manufacture durable fuel cells, longer lasting batteries and better solar panels. “No one can match our quality and volume,” explains David Himebaugh, company president. “We can make more material in a month than anyone else can in a year.”

Although it is focused on the energy sector, its nanotech materials have a wide variety of other uses and potential uses in automotive, adhesives, photonics, electronics, health care, and other sectors. Blue Nano’s unique manufacturing process makes its products more cost effective for many uses, Himebaugh says.

Working in the world of the very small—there are 25.4 million nanometers in one inch—requires quite specialized knowledge. Even the physical properties of materials change at that ultra tiny scale. “Inert things become combustible, transparent ones become opaque. The rules are different,” explains Himebaugh.

The company’s Chief Technology Officer, Chang Chen developed the original process while in school at North Carolina State University, but Blue Nano has added many additional scientists and advanced the process considerably since the company was founded in 2007.

“The process is key,” he says. “We’re able to customize lengths and diameters and do it all in very high quality and high volume, so it’s cost effective.”

The company can take any of the natural elements it works with, copper, gold, silver, and so forth and cost-effectively create more surface area on them at the nanoscale. “That’s what we found the key to doing,” Himebaugh says.

A manufacturer using a gram of nanotech silver powder in a product could gain 3,000 times more surface area with a gram of Blue Nano’s silver wires, he says. That allows more efficient chemical reactions and lets the manufacturer use less material.

Blue Nano’s CAT-110 fuel cell catalyst begins with a thin, sponge-like membrane made out of gold. Platinum is then evenly coated across the top of the sponge at a thickness of only one nanometer. “Below that, you’re at the atomic level,” Himebaugh notes.

“Our stuff is good, durable, and less expensive,” he adds. Among other things, it increases fuel cell power density and far exceeds the Department of Energy’s performance standards for 2015. “Fuel cells are going to be powering quite a few things, from laptops to vehicles,” says Himebaugh, “and we can bring that much closer to happening, much quicker than people thought.”

The 15-employee company is self-funded. It sells its materials to original equipment manufacturers. It is one of 60 innovative companies presenting at the upcoming Southeast Venture Conference in Tysons Corner, VA, Feb. 24-25 (see: www.seventure.org).

Online: www.bluenanoinc.com

Tiny nanofactories may stop infections without antibiotics

Wednesday, January 27th, 2010

Professor William Bentley

COLLEGE PARK, MD -  New research at the A. James Clark School of Engineering could prevent bacterial infections using tiny  biochemical machines-nanofactories-that can confuse bacteria and stop them from spreading, without the use of antibiotics.

We remember reading Dr. K. Eric Drexler’s 1986 book, “The Engines of Creation,” which suggested that eventually medicine might develop submicroscopic factories much like this to battle disease on a molecular level. Drexler’s ideas about the atomic-sized machines sounded like science fiction at the time.

But this research brings his ideas startlingly to life.

A paper about the research is featured in the current issue of Nature Nanotechnology.

The work is an update on the researchers’ original nanofactories, first developed in 2007. Those nanofactories made use of tiny magnetic bits  to guide them to the infection site.

Nanofactories recognize good from bad bacteria

William Bentley, professor and chair, Fischell Department of Bioengineering at the Clark School says “This is a completely new, all-biological version. The new nanofactories are self-guided and targeted.”

Bentley advised the research group, which included Clark School alumnus Rohan Fernandes (Ph.D. ’08, bioengineering), graduate  student Varnika Roy (molecular and cell biology), and graduate student Hsuan-Chen Wu (bioengineering).

The new nanofactories can tell the difference between bad (pathogenic) and good bacteria. For instance, our digestive tracts contain a  certain level of good bacteria to help us digest food. The new nanofactories could target just the bad bacteria, without disrupting the levels  of good bacteria in the digestive tract (a common side effect of many antibiotics). Nanofactories target the bacteria directly rather than  traveling throughout the body, another advantage over traditional antibiotics.

Disrupts communication

Bacterial cells talk to each other in a form of cell-to-cell communication known as quorum sensing. When the cells sense that they have  reached a certain quantity, an infection could be triggered. The biological nanofactories developed at the Clark School can interrupt this  communication, disrupting the actions of the cells and shutting down an infection.

Alternatively, the nanofactories could trick the bacteria into sensing a quorum too early. Doing so would trigger the bacteria to try to form an  infection before there are enough bacterial cells to do harm. This would prompt a natural immune system response capable of stopping  them without the use of drugs.

Because nanofactories are designed to affect communication instead of trying to kill the bacteria, they could help treat illness in cases  where a strain of bacteria has become resistant to antibiotics.

May have other benefits

The nanofactories’ ability to alter cell-to-cell communication isn’t limited to fighting infections.

“Quorum sensing and signaling molecules are actually used to accomplish a lot of things,” Bentley explains. “Sometimes disease develops  because communication is not taking place-a good example is digestive disorders that involve an imbalance of bacteria in the digestive  tract. In that case, nanofactories could be used to start or increase communication instead of disrupting it.”

“The work by Dr. Bentley is extremely exciting as he is using the ability of engineering to “build” using nature based components,” says  Philip Leduc, associate professor in the Departments of Mechanical and Biomedical Engineering at Carnegie Mellon University. “Understanding the science of cells is wonderful, but then  using these components and constructing systems that leverage biological advantages is a huge step forward.”

Read the article at Nature Nanotechnology (http://www.nature.com/nnano/journal/vaop/ncurrent/full/nnano.2009.457.html)

Visit Professor Bentley’s web site (http://www.bioe.umd.edu/~bentley/)

See a research overview at the Biochip Collaborative web site (http://biochip.umd.edu/bentley/index.html)

NC lands in top ten states as nanotech hub

Thursday, September 24th, 2009

RALEIGH, NC – North Carolina ranked eighth among the top ten states with concentrations of nanotechnology companies, according to a study by the Project of Emerging Technologies.

A partnership betwen the Woodrow Wilson International Center for Scholars and the Pew Charitable Trust, the Project ranked California number one and Massachusetts number two on the list of the top ten nanotech states.

“Nanotechnology is fundamental to North Carolina’s economic development strategy of growing jobs and building a new economy,” Gov. Beverly Perdue said in a statement.

“As one of the Top 10 nanotech states, North Carolina will continue to push ahead and lead a technology sector that will change every industry and create products that will change the way we live.”

NC ranked eighth in the number of nanotech companies, with 37 and sixth in number of academic and research labs, with eight.

Raleigh was in the top five cities with a nano cluster, third behind Boston and San Jose, CA as a Nano Metro, with 34 firms and research projects.

Fourth annual SEVC set for Feb. 24-25 in Virginia

Wednesday, September 16th, 2009

RALEIGH, NC – The 2010 Southeast Venture Conference (SEVC) is set for February 24-25 at the Ritz Carlton in Tysons Corner, Virginia. The sold-out 2007, 2008 and 2009 SEVCs featured over $80 billion in private equity investment capital in attendance.

The fourth annual SEVC will feature approximately 75 of the southeast region’s top private technology firms, dozens of high profile speakers and exclusive panels geared toward a national audience of venture capitalists, private equity investors, and executive entrepreneurs.

The SEVC has featured over 80 of the most dynamic technology and business speakers including names like craigslist founder Craig Newmark, Forbes publisher Rich Karlgaard, mega-VC Tim Draper, Senator Mark Warner, former Apple CEO John Sculley, SAS CEO Dr. Jim Goodnight and Salesforce.com president Jim Steele to name a few. SEVC speakers are thought leaders who inform, educate and inspire the leaders of the new economy.

SEVC presenting companies will range from early stage firms seeking their first institutional round to later stage pre-IPO firms seeking expansion capital.

Presenting companies are high growth, innovative companies with talented management teams, proprietary technology and headquartered in one of the following: Alabama, Florida, Georgia, Maryland, Mississippi, North Carolina, South Carolina, Tennessee, Virginia or Washington DC.

The SEVC is the opportunity for private equity investors to network with the most promising emerging growth companies in the southeast region and for pioneering entrepreneurs to make the connections that empower their companies to become tomorrow’s business leaders.

The SEVC strives to support entrepreneurial activity, innovation and the resultant economic development of the Southeast.

TechJournal South is a major sponsor of the SEVC.

Online: www.seventure.org

Wake-Forest researchers zap prostate tumors in mice

Wednesday, September 9th, 2009

WINSTON-SALEM, NC – Researchers at Wake Forest University School of Medicine have destroyed prostate cancer tumors in mice by injecting them with specially-coated, miniscule carbon tubes and then superheating the tubes with a brief zap of a laser.

The procedure, which used DNA-encased, multi-walled carbon nanotubes (MWCNTs) to treat human prostate cancer tumors in mice, left only a small burn on the skin that healed within days.

“That we could eradicate the tumor mass and not harm the tissue is truly amazing,” said principal investigator William H. Gmeiner, Ph.D., a professor of cancer biology at the School of Medicine.

The researchers envision using the particles not only to kill tumors through heating, but also to target cancer drugs to the diseased area in patients.

The long-term goal in the project is to be able to use the technology for “a variety of types of tumors,” Gmeiner said.

Carbon nanotubes are sub-microscopic particles that have been the subject of intense cancer research.

The MWCNTs used in the current study consist of several nanotubes that “fit inside one another like Russian dolls,” Gmeiner said. The MWCNTs are injected into a tumor and then heated with laser-generated near-infrared radiation.

For this study, the tubes were injected into human prostate cancer tumors being grown in mice. The radiation causes the tubes to vibrate, creating heat. That heat kills the cancer cells near the nanotubes. If there are enough nanotubes, the amount of heat generated can kill whole tumors.

For this study, researchers used MWCNTs encased with DNA, which prevented them from bunching up in the tumor, allowing them to heat more efficiently at a lower level of radiation and leaving the surrounding tissue virtually unharmed.

With funding from the National Cancer Institute and the North Carolina Biotechnology Center, researchers grew 24 prostate cancer tumors in 12 mice. They then separated the mice into groups receiving treatment with DNA-encased MWCNTs and laser, laser only, non-DNA-encased MWCNTs only, or no treatment.

The eight tumors treated with a single injection of DNA-encased MWCNTs and zapped with a 70-second burst from a three-watt laser were gone within six days after treatment. While a minor surface burn appeared at the site of laser treatment, it healed within a few days with antibiotic ointment, Gmeiner said.

The tumors in the other treatment groups showed no distinguishable reduction.

Using the DNA-encased MWCNTs increased heat production two- to threefold – allowing researchers to use fewer nanotubes and a less powerful laser to kill tumors – an important consideration as scientists determine potential issues with the toxicity of nanotubes, since they remain in the body after treatment, Gmeiner said.

Current thermal ablation, or heat therapy, treatments for human tumors include radiofrequency ablation, which causes regional heating between two electrodes implanted in tissue but cannot be used to selectively distinguish cancer cells from healthy cells, like researchers hope they will be able to do with MWCNTs.

In addition to the DNA-encased MWCNTs used in this study, other nanomaterials, such as single-walled carbon nanotubes and gold nanoshells, are also currently undergoing experimental investigation as cancer therapies.

Before treatment with MWCNTs can be tested in humans, studies need to be done to test the toxicity and safety, looking to see if the treatment causes any changes to organs over time, as well as the pharmacology of the treatment, to see what happens to the nanotubes, which are synthetic materials, over time.

An advance copy of the study is now available in the online edition of ACS Nano and the full paper is scheduled to appear in a future print issue.

Techulon raises $400K to commercialize Virginia Tech IP

Tuesday, July 21st, 2009

By Allan Maurer

EXCLUSIVE REPORT ALEXANDRIA, VA – Techulon Inc., a company formed to acquire licenses to make and sell products based on intellectual property from Virginia Tech, has raised a total of about $400,000 from the members of Tech’s Science Advisory Council. CEO and President Frank Akers tells TechJournal South the company has already selected a couple of ideas to work on and is in the process of securing licensing rights.

One project involves drug discovery and another biopolymer technology, Akers says.

The company, originally founded in 2006 actually began operations after hiring Akers in May 2008. It plans to hire its first employee, a chief scientist, Sept. 1.

A Virginia Tech alumni with a degree in chemistry, Akers previously founded the West Coast telecom industry firm, GoDigital, which sold in 2006.

Newsweek magazine ranked Virginia Tech 5th among U.S. universities in biopolymer science and Akers says the company has seven prominent biopolymer scientists on its Polymer Science Advisory board.

Wikipedia says biopolymers are a class of polymers produced by living organisms. Cellulose and starch, proteins and peptides, and DNA and RNA are all examples of biopolymers, in which the monomeric units, respectively, are sugars, amino acids, and nucleotides.

Akers notes that advanced biopolymers are beginning to be used in medicine and therapeutic applications. One use is to make nanoparticles of almost anything, says Akers. “That gives you a way to transport, package or vector them for various applications,” he says.

Techulon will invest in an infrastructure for that business.

The company’s board includes several serial entrepreneurs, Akers says. “They speak the tech lingo but know how to run companies. They’ll be heavily involved in operations.”

Virginia Tech’s emphasis on practical research aids the company in finding IP to take to market, Akers says. “Their IP is closer to being available for licensing to make and sell products, not just blue sky kind of stuff,” he says.

“We’re on the cusp of several things we can talk about in a couple of weeks, but we’re making great progress.”

He adds that the company hopes to have products and revenue by next year.

Medtronic invests additional $2.5M in NC-based NanoCor Therapeutics

Wednesday, July 1st, 2009

CHAPEL HILL, NC – Minneapolis-based Medtronic Inc. has invested an additional $2.5 million in NanoCor Therapeutics Inc., a company developing a gene-based therapy for congestive heart failure. The investment brings the total Medtronic has invested in NanoCor to $6.5 million.

Medtronic has also agreed to invest additional amounts upon Nanocor’s meeting of certain milestones.

NanoCor is planning to supplement Medtronic’s current and future investments with additional funding from institutional investors.

NanoCor, an affiliate of Chapel Hill-based Asklepios BioPharmaceutical Inc. (AskBio), was created to focus on therapeutic cardiac applications and is engaged in the research and development of proprietary treatments for CHF.

Congestive heart failure, also called congestive cardiac failure or heart failure, is a condition in which the heart is unable to supply sufficient amounts of blood and oxygen to the body.

The American Heart Association estimates that approximately five million patients in the United States and over fifteen million patients worldwide suffer from CHF with over 500,000 new cases diagnosed each year.

NanoCor’s therapeutic is comprised of the delivery of a proprietary gene developed at the Massachusetts General Hospital and the University of Cincinnati.

The gene will be delivered with AskBio’s proprietary Biological NanoParticle (BNP)and the Self-Complementary vector technologies, which are derived from human adeno-associated virus vecto.

This technology was developed at the University of North Carolina at Chapel Hill and was exclusively licensed to NanoCor.

AskBio was spun out of the University of North Carolina at Chapel Hill and is engaged in the development of novel, intracellular protein therapeutics using its BNP and Self-Complementary technologies. BNPs may be used to target delivery of a broad variety of biological material, including therapeutic genes, RNAi, and vaccines, among others, to specific tissues.

Sheila Mikhail, Chief Executive Officer of NanoCor said, “We are pleased to have an additional investment from one of the world’s most respected medical technology companies, especially in these difficult economic times. This investment is a very important step towards providing a non-invasive treatment option for the millions of patients suffering from this debilitating disease.”

Previously on TechJournal South:

Medtronic invests $3.75M in NanoCor:

http://techjournalsouth.com/news/article.html?item_id=3848

Start-up testing gene-based treatment for arthritis:

http://techjournalsouth.com/news/article.html?item_id=6711

Online:www.nanocorthx.com; www.askbio.com

Nanobiotech Center wins $2.5 million, 4-year grant

Wednesday, June 17th, 2009

RESEARCH TRIANGLE PARK – The North Carolina Biotechnology Center has approved a four-year, $2.5 million grant for the NC Triad-based Center of Innovation in Nanobiotechnology (COIN). The center plans to develop the commercial potential of nanobiotechnology research from universities across the state.

“Nanobiotechnology is an exciting new discipline that has the potential to change everything from textiles to medical devices. This Center of Innovation will help commercialize more of the nanobiotech breakthroughs being made in North Carolina laboratories,” said Mary Beth Thomas, senior director of the Centers of Innovation program at the Biotechnology Center.

Nanotechnology involves structures between one and 100 nanometers in size—roughly 10,000 times thinner than a sheet of paper. Companies in North Carolina are already working on nanoparticles that treat disease by carrying new genes to certain cells, and sunlight-powered nano-scale coatings that kill microbes on hard surfaces and fabrics

The four-year award to COIN builds on a $100,000 planning grant given by the Biotechnology Center last year. That money was used to hire an executive director and develop a business plan, making the Nanobiotech Center eligible for the current round of funding. With the new award, COIN will establish itself as an independent, self-sustaining entity. The $2.5 million will be paid as business milestones are reached.

Key partners in the planning effort included North Carolina Agricultural and Technical State University, the University of North Carolina at Greensboro and Wake Forest University.

Biotech veteran Brooks Adams was hired in January to be executive director of the planning effort and will assume the same role in the independent COIN.

In accord with the Center of Innovation program’s statewide purview, the COIN core group now includes Duke University, North Carolina State University, the University of North Carolina at Chapel Hill and UNC-Charlotte.

COIN is one of four Centers of Innovation created by the Biotechnology Center to accelerate commercialization in areas of particular economic promise, including marine biotechnology, drug discovery, and advanced medical technologies.

In addition to their technology-development efforts, the Centers will coordinate research leading to commercial opportunities and sector development.

Online: www.nc.biotech.org

Florida’s Tamiami Angel Fund raises $200K of $4.3M

Wednesday, June 17th, 2009

By Allan Maurer
NAPLES, FL—The Tamiami Angel Fund (TAFI) created following the Southwest Florida Regional Angel Fund Assessment and legislation passed by the Florida legislature in 2007 creating the Florida Capital Formation Act and the Florida Opportunity Fund, has raised at least $200,000 of a fund targeted at $4.3 million.

The fund, originally targeted at $3 million is now aimed at $4.3 million according to a filing with the U.S. Securities and Exchange Commission that reveals it has so far raised $200,000.

According to the fund’s web site, TAFI is to be a for profit member-owned and member-managed limited liability company, organized to provide Members an opportunity for active involvement in a diversified capital investment process and a portfolio of Florida based emerging growth companies.

The fund’s strategy and model for early stage investing will leverage an investment committee approach and a mentorship philosophy, establishing an organization through which Angels, as former successful executives, and entrepreneurs can remain involved in business investing.

It plans to invest in early stage, high growth companies primarily in the Southwest Florida region and throughout the state.

The fund will hold monthly meetings beginning in October and running through May where it will present emerging companies to its members.
The meetings are limited to accredited investors.

It will invest emerging companies in biotech, business products and services, the Internet and web services, clean tech, education, medical devices and equipment, education, electronics and instrumentation, telecommunications, healthcare services and nanotechnology.

Online: www.tamiamiangels.com

Pixelligent Tech grabs $2M round for nanotech apps

Friday, May 29th, 2009

COLLEGE PARK, MD—Pixelligent Technologies, a company developing nanotechnology applications in optical lithography and nanocomposites for the semiconductor and microelectronics markets, has raised a $2 million round from angel investors, a West Coast entrepreneur, and the company’s management team.

“We were one of the first to recognize the potential of using nanotechnology in critical optical lithography applications for the semiconductor industry and we are now expanding this technology into other related fields,” said Greg Cooper, PhD, President of Pixelligent.

“This funding, in combination with the support we have received from federal grant programs, has enabled us to support our world class nanotechnology team and move our technology closer to the market.”

The company says its technologies extend the use of current chip manufacturing technology, promising improved performance and cost savings for chip makers.

Its Reversible Contrast Enhancement Layer is a liquid-based lithographic solution which contains dispersed nanocrystals that act to focus light. This improves the resolution of lithography, enabling more transistors to be printed on each chip.

It also developed a process to enhance phtoelectrochemical hydrogen production while increasing the reliability of the process. This breakthrough could result in significantly cheaper fuel that could be used in many applications including, powering vehicles.

Founded in 2000, Pixelligent was named Maryland Incubator Company of the year in 2005. It has won millions of federal grant funding dollars from the National Institute of Standards, the National Science Foundation and the Small Business Innovation Research program.

Headquarted in the University of Maryland incubator building, Pixelligent has a team of ten PHD experts in nanotechnology who have published more than 200 peer reviewed papers and articles.

Online: www.pixelligent.com

Axion BioSystems closes $1 million round

Monday, May 4th, 2009

EXCLUSIVE REPORT ATLANTA—Axion BioSystems Inc., which has developed an advanced microelectrode array technology for research, clinical and drug discovery markets, has raised slightly more than $1 million in a friends and family round of funding. Axion president and CEO Tom O’Brien tells TechJournal South the money should be enough to get its products to market and producing revenue this year.

The company previously received funding and support from the Georgia Research Alliance and its VentureLab, which was created to help move research at the state’s universities into commercial markets.

The 9-employee company’s technology came from out of Georgia Tech’s NeuroLab and Axion is conveniently located in the Advanced Technology and Development Center near the campus. “We have a great collaboration with Georgia Tech and a growing one with Emory,” says O’Brien.

“Our operations are located in the ATDC Bioscience center, in close proximity Georgia Tech’s NeuroLab , so it’s a good place for us to be,” he says. It’s also close to the Petit Microelectronics Research Center (MiRC), the biomedical hub of the National Nanotechnology Infrastructure Network (NNIN).

MiRC includes cutting edge tolls for micro and nanofabrication, while NeuroLab provides access to rapid prototyping tools, machine shop facilities and specialized electronics testing equipment for neural research.

James Ross, Ph.D., Axion’s chief technical officer, was previously a product development engineer for Advanced Micro Devices and the co-founder and Chief Technology Officer of Teneo Micro Instruments.

During his tenure at the Microelectronics Research Center and the Laboratory for Neuroengineering, he was instrumental in producing over a dozen critically enabling technologies for the manipulation and sensing of neural tissue (many of which are patent pending).

Chief Engineer Edgar Brown is currently a research engineer at the Laboratory for Neuroengineering in Atlanta, Georgia. He possesses more than 20 years experience in analog, digital, and mixed signal circuit design.

Swaminathan Rajaraman, the company’s MEMS Engineer, is currently working toward his PhD degree in Electrical Engineering at Georgia Tech.

He has over 10 years of academic and industrial research experience in MEMS, biotechnology and semiconductors. He has previously worked with Analog Devices and CardioMEMS in developing MEMS fabrication technologies for optical micro-mirrors and implantable sensors respectively.

Axion’s proprietary technology allows simultaneous stimulation and recording of neural tissue—an industry first—and includes low-power chips that service thousands of channels.

O’Brien says the company’s products will allow faster drug-screening than current ones, among other advantages. It electronically stimulates live cells and records their reaction.

While its current development is focused on pharmaceutical drug screening, ongoing development will result in devices in the medical arena, the company says.

O’Brien says Axion is fairly close to getting its first drug screening product out and does not anticipate seeking more money now.

O’Brien was most recently a senior executive at Philips Medical Systems, a division of Royal Dutch Philips, after the sale of Intermagnetics. At Intermagnetics Tom held the role of executive vice president, Corporate Development and president, Invivo Medical Devices.

“Financially, we’re in good shape,” O’Brien says. “We have a modest burn and this should be enough to carry us for a couple of years.”

Online: www.axionbiosystems.com

Seven Maryland startups get TEDCO funding

Thursday, April 2nd, 2009

COLUMBIA, MD – The Maryland Technology Development Corporation (TEDCO) says seven Maryland technology companies have received $512,637 total in funding.

Chesapeake Micro Products, LLC; Fyodor Biotechnologies, Inc.; Green Eyes, LLC; Rafagen, Inc.; SD Nanosciences, Inc.; Tendyne Medical, Inc.; and Vorbeck Materials Corporation, each received approximately $75,000 from TEDCO’s Maryland Technology Transfer Fund (MTTF).

“Maryland’s Technology Transfer Fund, administered through TEDCO, plays a critical role in economic development and job creation here in our State,” said Governor O’Malley.

“The fund fosters the development and commercialization of innovative technologies in Maryland’s private sector, providing the tools for these start ups to thrive and contribute positively to the State’s economy for the long term.”

• Chesapeake Micro Products, located in Salisbury, Md., is working with the Beltsville Agricultural Research Center (BARC) to develop a manufacturing process to convert chicken feathers into pellets for injection molding machines in order to create biodegradable horticultural pots and plastic products.

• Fyodor Biotechnologies Inc., located in Baltimore, is working with Johns Hopkins University to develop blood-based malaria tests to detect intact proteins in the blood for malaria patients.

The technology is performed and read within minutes, and will offer a more valuable tool for the management of clinical malaria.

• Green Eyes, located in Easton, Md., is working with the University of Maryland Center for Environmental Science to commercialize its ProbeGuard and Water to Web products. ProbeGuard controls the accumulation of organisms on various moored aquatic instruments.

The system will automatically collect data from field deployed water quality monitors and display that data on public or private internet sites minutes after collection.

• Rafagen Inc., located in Rockville, Md., is working with University of Maryland Biotechnology Institute to further develop and commercialize a next generation gene expression system which can be applied to solving problems in molecular therapeutics.

Applying Rafagen’s synthetic gene promoters will lead to dramatic reduction in the cost of biotherapeutics manufacturing and the development of gene and cell-based drugs with minimum toxicity.

• SD Nanosciences, Inc., located in Beltsville, Md., is working with the University of Maryland College Park to further develop patent-pending carbohydrate-functionalized nanomaterials.

Their vesicle technology, Targeted Delivery Vesicles, encapsulates and target drugs and can be stored and shipped as a stable liquid at room temperature.

SD Nanosciences also has demonstrated their TRIAD technology which uses gold nanoparticle presenting carbohydrates capable of eliciting a potent IgG response directed against polysaccharide and generate a maximal antibody response.

•Tendyne Medical Inc., located in Baltimore, is working with the University of Maryland Baltimore to develop and manufacture medical devices that address the features of structural heart disease. This technology will focus on developing minimally invasive devices.

• Vorbeck Materials Corp., located in Jessup, Md., is working with the Army Research Laboratory to develop and manufacture applications using Vor-x, Vorbeck’s novel graphene material as an electrical contact to semiconductor materials like silicon and silicon carbide.

The results and technical know-how generated as part of this study will be used to identify applications for these contacts in both mainstream and niche electronics applications.

Online: www.MarylandTEDCO.org.

SURA promotes tech transfer throughout the Southeast

Tuesday, March 24th, 2009

By Allan Maurer
WASHINGTON, DC—The Southeastern Universities Research Association (SURA), a consortium of more than 60 universities and colleges in 16 states, primarily in the Southeast, has a mission. “Our biggest marching order is to strengthen science and technology in the Southeast and the nation,” says Marc Oettinger, the organization’s associate director business development and commercialization.

It focuses, says Oettinger, on information technology, nuclear physics, technology commercialization, and coastal research.

“Under IT, it’s high performance initiatives help create cyber infrastructure across the states so its universities and colleges have specialized HPC access, and gateways to national and international cyberinfrastructure,” Oettinger says.

SURA also jointly operates the Thomas Jefferson National Accelerator facility in Newport News, VA. JLab, as it’s known, is a world class research facility for both basic and applied research of the atom’s nucleus at the quark level. With industry and university partners, JLab also reaches out to help educate the next generation in accelerator science and technology.

Technologies currently listed on its tech transfer Web site include a nuclear cargo detector and a method to improve detection of cancerous lesions and medical imaging device improvements, among others.

Founded in 1980 as a nonprofit corp., SURA fosters collaboration among its member institutions in science and engineering.

It also promotes and supports technology transfer of JLAB and member university inventions and technologies, Oettinger says. “We help supplement their licensing opportunities and help build start-ups centered on novel technologies.”

“Those efforts include the SURA Venture Forum, a quarterly virtual event that enables efficient dealflow and connects select investors with untapped early-stage technology teams … we’ve held it for five quarters now, starting in Q1 of 2007,” Oettinger says.

While the Venture Forum’s pilot event resulting in a funding, “There hasn’t been one since,” he says. “We work with nine VC firms, connected to their investment criteria and interests. We produce fundable teams. But it’s tough in this climate. It’s focused on early, seed stage investments of $100,000 to $1 million.”

To date, he says, SURA has produced more than 100 opportunities. “Our ultimate goal is to put them in a searchable database form,” says Oettinger.

SURA also holds symposia and competitions designed to enhance applied research and technology transfer, he says. “They’re designed to vet and spin out commercial opportunities.”

It co-sponsors an event called “The World’s Best Technology Showcase” in Arlington, Texas annually that brings together early stage investors and technologies, “First in their space and close to market,” says Oettinger.

In the mid-80’s, SURAnet was created as the first regional IT network. Initially funded by the National Science Foundation, it was sold to the private sector in 1995. A major new SURA initiative in coastal research began in 2001.

Several Southeastern states have growing coastal research clusters, including one in Carteret County on North Carolina’s East Coast that some say might one day rival Woods Hole.

Online: www.sura.org

Tampa-based Nanobac Pharma proposes merger

Tuesday, March 17th, 2009

TAMPA BAY, FL – Nanobac Pharmaceuticals Inc. (PINK SHEETS: NNBP) has signed an memorandum of understanding describing a potential merger with Eureka Genomics.

The proposed merger would include a reverse stock split of Nanobac shares. Nanobac would issue new shares of its common stock to Eureka. Eureka would own 90 percent of the combined firm, which would operate as Eureka Genomics.

California-based Eureka has a proprietary genomics platform for diagnostics, therapeutics, vaccines and cleantech product development.

Nanoback focuses on treating nanobacteria.

Five startups presenting at Grubstake event in N. Virginia

Monday, March 9th, 2009

FAIRFAX, VA, – Five young technology companies seeking $250,000 to $2 million in financing have been been selected to present their business plans at the March 19 Grubstake Breakfast at the Ritz Carlton in Tysons Corner, VA.

The Grubstake Breakfast, sponsored by the Business Alliance of George Mason University, is the Mid-Atlantic’s longest running networking and investors forum.

More than 200 early stage investors, angel investors and companies seeking to acquire or learn about the latest technology are expected to attend. The five presenting companies selected are:

ChicksWithKidz (Alexandria, VA) is the developer of bizzyBee, the first Baby Data Assistant–a portable recordation and notification device that is used to notify parents/caregivers regarding times to medicate sick children and other critical data.

Eye Controls, LLC (Chantilly, VA) designs and manufactures the patent-pending SafeMatch® iris identification system for use with electronic medical records to positively ID patients to the correct record. Also, positive ID is needed for patient record access and e-prescribing functions.

Mingle360 (Fairfax, VA) is a social connectivity platform that makes it easier for consumers to safely connect with each other, with vendors and with product of interests using a minglestick to tag these contacts at an event and then later retrieve information about them from the Internet.

Pixelligent Technologies, LLC (College Park, MD) is a nanotechnology company whose leading innovation is centered around lithographic applications used in integrated circuit design enabling more transistors to be printed on each chip increasing each chip’s processing capacity.

SitScape’s (Vienna, VA) enterprise software empowers business users to see the most important and relevant information to them at glance through visual personalized dashboards which can be easily assembled in minutes using live data on disparate Web applications/external sites.

Three other young technology companies will also be spotlighted at the Grubstake Breakfast:

Dalos BioPharma (Virginia Beach, VA) produces naturally-occurring botanical products derived from a proprietary single source for the use of combating bacterial and viral infections of the skin (e.g. MRSA and other Staphylococcus-related skin infections and Molluscum contagiosum and other viral skin diseases).

Turiss (Reston, VA) provides information security services and cyberfraud prevention software using cutting edge cyber-intelligence reports and alerts to financial institution clients based on intelligence generated by its civil intelligence network.

Viscape, LTD (Arlington, VA) is an industry disruptor offering a free listing and lead-generation service for vacation property businesses on a social networking platform.

For more information on the Business Alliance Grubstake Breakfast, or to register to attend, see:

www.businessalliance.org/grubstake-registration.html.

Maryland seeks nanobiotechnology proposals

Thursday, February 19th, 2009

BALTIMORE, MD – Three Maryland groups, the Maryland Department of Business and Economic Development, the Maryland Technology Development Corp., and the Maryland Biotechnology Center have issued a call for nanobiotechnology proposals in a new grant competition.

Each winning company, university or non-profit will receive up to $250,000 for a nanobiotech research project of no more than two years.

Contestants must be Maryland-based and submit letters of intent by March 13, and a full proposal by April 17.

Specialized nanobiotech centers have been established at both the University of Maryland and John Hopkins University the last couple of years.

Online: www.marylandtedco.org

NC Biotech industry surveyed as CED’s Biotech 2009 opens

Monday, February 16th, 2009

RESEARCH TRIANGLE PARK, NC—North Carolina Governor Beverley Purdue will be the opening speaker at the NC Council for Entrepreneurial Development’s annual two-day Biotech 2009 event today at the Raleigh Convention Center. In a podcast interview preceding the event, Steven Burke, vice president of corporate affairs at the NC Biotechnology Center took a wide-ranging view of how North Carolina became a major biotech hub and the importance of the industry to the state’s future.

In the podcast interview conducted by Raleigh-based public relations firm MMI Associates, Burke points out that NC already boasts more than 500 companies and 56,000 workers in the biotechnology sector. “It is an enormously pervasive, enormously well-positioned and enormously important industry across this state,” Burke says.

“We have in biotechnology a lead sector for the economic vitality of North Carolina for the next 25 years.”

While the Research Triangle region is well-known for its biotechnology cluster, Burke notes that because the biotech industry “deals with everything from agriculture to food from trees to drugs,” it is “largely positioned across the state and yields applications across the state.”

Burke acknowledges that the biotech industry is pervasive and competitive worldwide. Indeed, in the Southeast alone, South Florida climbed quickly into a top ten spot and Atlanta is coming along as a player.

North Carolina’s biotech industry, says Burke, “is particularly rich, dynamic, engaged and successful – and probably for three main reasons.”

“The first reason for our success is the breadth of the range of biotechnology in North Carolina.”

The state biotech industry, he says, “addresses pharmaceuticals and biofuels, native plants and trees, regenerative medicines and nanobiotechnology, marine resources and plants altered to produce proteins, new industrial processes and ways to look at the health of swine and poultry.”

The Biotech Center also often notes that North Carolina has vast forest and plant resources in the West, a growing marine biotechnology cluster on the Eastern coast, rural areas suitable to large biotech manufacturing facilities, and not only the three large research universities anchoring the Triangle, but also a robust community college system and other sizeable universities.

Second, he says, the reality of the state’s accomplishments in the industry over a period of years.

“Our outcomes from that science are strong in company activities, in products developed here. This is, after all, a state judged the third-leading place in America for biotechnology outcomes.”

The third reason, he says, is “the unusually strong predisposition of so many diverse biotechnology parties to work together.

“To create a product in biotechnology requires some science, some research, some funding, some commercialization, an educated workforce, training per persons. It requires that products be tested and tried. It requires that policies be appropriate. So many different groups must work productively together for the end result, which is a single product or application benefitting every one of us.”

How it got there
Burke, asked to detail the history of biotech in NC replied, “North Carolina was the first place or state to create a targeted initiative to bring about biotechnology as a matter of long-term state policy and a matter of long-term state gain. Gov. Jim Hunt, one of the speakers at the Biotech 2009 conference, effected in his first term as governor the establishment of the North Carolina Biotechnology Center 25 years ago.

“So, North Carolina, unique among places worldwide, has one quarter-century of history in developing biotechnology. Twenty-five years of experience in how to strengthen our university researchers and our university science, of experience in creating and funding and sustaining small companies, of experience in strategies for the often-daunting task of financing those companies, of strategies for taking science from the laboratory out to a company and to a field and to a hospital room.”

He adds, “North Carolina also has – and we must count this as very important – 25 years of history in making this technology a sustained matter of state policy, of state attention and of state commitment.” The value of doing that is not only the strength of the sector in NC now, but also the promise it holds for the next 25 years, he says.

Resources for startups

Burke outlines the steps a biotech must take, from an idea aimed at solving a serious social need, the science or research necessary to find an answer, initial funding to do experimental work and then with commercialization, testing, and ways to make and sell the product.

“What a lot of stages,” Burke says. “And they are all different.”

North Carolina, he says, “benefits from access to and partnership with good university researchers. A company benefits from good ways to do what’s called technology transfer, which is to take promising ideas from university laboratories to the world of the company.

“Companies here benefit from financing assistance, from venture capital and from other sources. Companies here benefit from the resources needed to test their product and to help move it to verification, be it with the help of a contract research organization – and North Carolina is the leading place in the country for such firms – or help from a research station to enable trial growing.”

But that’s not all. He continues, “In North Carolina, we have a community college training program that’s unparalleled nationwide. And a company also wants assurance that it is going to be in a place in which long-term state policy and long-term state leadership is very much committed to biotechnology and to making that company successful.”

In North Carolina, he says, biotech companies know “there is a predisposition to help them through the Biotechnology Center or other state agencies.”

Burke admits that “We are clearly in a time of economic travail,” and nothing is likely to be exempt.

“The reality, though,” he says, “of enormous benefit is that even in times of acute economic challenge and downtown, society will always need and cries for and will ultimately fund the development of new drugs, new ways to diagnose and treat disease.

“Society will always need more productive ways to use our fields, to grow food, to grow animals, to ensure the health and vitality of agriculture. Society will increasingly need new alternatives to petroleum-based fuels. Society will need biofuel. Our society will need new solutions for cancer, new solutions for industrial processes.

“So, among the areas of society, in the short term at present, likely to be at some degree buffeted by economic downturn, biotechnology is likely to be among those that will have promise to regroup and regain to be strengthened fairly quickly.”

For the entire podcast see:

http://tiny.pl/vbvj