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Posts Tagged ‘Wake Forest Unversity’

Mutant green tomatoes show researchers key to tougher crops

Thursday, September 2nd, 2010

tomatoesWINSTON-SALEM, NC – As fat summer tomatoes dangle in profusion from vines in gardens and farms across the country, researchers at Wake Forest University are looking for a way to make future harvests hold up better against drought or lack of nutrients.

But the tomatoes these researchers study, with names like Never Ripe and Green Ripe, are mutants that will never achieve that wonderful red that makes a perfect summer meal for many foodies.

That’s because Gloria K. Muday, Ph.D., a biology professor at Wake Forest, isn’t after a better fruit, at least not yet. She’s after a better root system.”If we can encourage tomato plants to form deeper root systems, those plants will be able to take in more water and pick up food more effectively,” Muday said.

And that could mean a more reliable harvest for farmers and backyard gardeners alike.

Key to ripening

The key, Muday said, is the relationship between the hormones auxin, a root growth stimulator, and ethylene, which is critical for the ripening of tomatoes, but which also influences the growth promoting effects of auxin.

Muday and her colleagues have discovered that ethylene also alters the development of root systems in tomatoes.
In research appearing in The Plant Journal, a peer-reviewed publication, Muday found that, in mutant tomatoes, ethylene limited lateral root growth; lateral roots form horizontally off the primary root to better anchor the plant in the soil. However, ethylene appeared to encourage root growth along stems and branches.

Pinpointing why ethylene has this effect can help plant biologists devise a plan for breeding or engineering tomato plants that grow more extensive root systems that can thrive despite dry conditions or lack of nutrients.
For the next step in this line of research, Muday is looking at other substances, including flavonoids, and how they influence hormones that stimulate root growth in tomatoes.

But for these experiments, she can savor the deeper colors of summer-ripe tomatoes, many of them heirloom varieties.

“There are all sorts of heirloom tomatoes – brown, purple, black – and we’re growing them now,” Muday said. “We’ll see how many of these compounds they make and how that effects the root development.”

The research is funded by the U.S. Department of Agriculture.

Regenerative tissue firm Tengion files for $40M IPO

Wednesday, March 17th, 2010
Dr. Anthony Atala, co-scientific founder, Tengion

Dr. Anthony Atala, co-scientific founder, Tengion

EAST NORRITON, PA – Tengion, a company that creates working organs using a patient’s own cells, plans to raise $40 million in an initial public offering of stock. Tengion has a research laboratory and pilot facility in Winston Salem, NC, where co-scientific founder Dr. Anthony Atala heads the Wake Forest Institute for Regenerative Medicine.

Tengion plans to offer 4.4 million shares at $8 to $10 a share. It will trade on Nasdaq under the symbol TNGN.

The company’s patented integrated technology platform  was developed over the past two decades by scientists at Children’s Hospital Boston (a teaching affiliate of Harvard Medical School), MIT, and the Wake Forest Institute for Regenerative Medicine.

It harnesses the body’s ability to regenerate tissues and organs, and has the potential to allow adults and children with organ failure to have functioning organs created from their own tissues.

Founded in 2003, the company has no revenue.

company owns or licenses over 30 US patents and patent applications and over 100 international patents and filings related to its platform and nine product candidates.

It has a urological treatment in Phase II clinical trials.

We have always been impressed with the progress of regenerative medicine in recent years and Dr. Atala’s work is at the forefront.

Dr. Atala and his lab have created working human bladders on cell scaffolds, a unique sort of construction work. Part of his research is funded by the U.S. Armed Forces. Regenerative technology could be a boon to wounded soldiers. It sounds like science fiction, but one day they may even be able to regrow injured limbs and replace severely damaged organs.

Dr. Atala conducted research and practiced pediatric urology at Harvard’s Children’s Hospital Boston for 15 years, until 2003, when he became Director of the Wake Forest Institute for Regenerative Medicine in North Carolina. Dr. Atala’s numerous awards and honors include the Christopher Columbus Foundation Award, funded by the US Congress and bestowed on a living American whose discoveries will significantly benefit society; and the Scientific American, Research Leader Award, for his contributions to tissue and organ regeneration.

Tengion’s corporate headquarters and commercial manufacturing facility are in East Norriton, Pennsylvania. The company has research offices, a development laboratory and a pilot manufacturing facility in Winston Salem.